Areas of expertise: Bioinformatics, Genomics, Proteomics, Metabolomics, Genetics
Richard is a Bioinformatician with over ten years experience in
the field. He obtained a BSc (Hons) in Biological Sciences from
Manchester Metropolitan University, UK, which was followed by an
MSc in Bioinformatics from the University of Manchester, UK. He was
subsequently appointed to the University of Cambridge, UK, at
Cambridge Institute for Medical Research, where he established a successful core bioinformatics facility, supporting some 200 wetlab scientists, as well as establishing facilities at three international collaborative sites.
Following on from the success of the CIMR facility he was appointed to TICHR in 2008 where he jointly leads and develops a programme of Bioinformatics for the Institute whilst also studying for a PhD in Bioinformatics at the University of Western Australia.
Richard has substantial knowledge in the application of a wide range of Bioinformatics methods to a broad spectrum of biological problems. His expertise primarily focuses on database design, the handling of large scale datasets (eg. Next Generation Sequencing data) and ultimately in developing visualisation systems and novel methods of data interpretation.
Francis RW, Thompson-Wicking K, Carter KW, Anderson D, Kees UR,
(2012) FusionFinder: A Software Tool to Identify Expressed Gene Fusion Candidates from RNA-Seq Data. PLoS ONE 7(6): e39987.
K Thompson-Wicking, R W Francis, A Stirnweiss, E Ferrari, M D Welch, E Baker, A R Murch, A M Gout, K W Carter, A K Charles, M B Phillips, U R Kees and A H Beesley (2012) Novel BRD4-NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma. Oncogene Nov 5. doi:
10.1038/onc.2012.487. [Epub ahead of print]
Selma P. Wiertsema, Lea-Ann S. Kirkham, Karli J. Corscadden, Eva N. Mowe, Jacinta M. Bowman, Peter Jacoby, Richard Francis, Shyan Vijayasekaran, Harvey L. Coates, Thomas V. Riley, Peter Richmond (2011) Predominance of nontypeable Haemophilus influenzae in children with otitis media following introduction of a 3 + 0 pneumococcal conjugate vaccine schedule Vaccine, 2011 May 27.
Fakiola, M., Miller, E.N., Fadl, M., Mohamed, H.S., Jamieson, S.E., Francis, R.W., Cordell, H.J., Peacock, C.S., Raju, M., Khalil, E.A., Elhassan, A., Musa, A.M., Fernando, F., Shaw, J.J., Sundar, S., Jeronimo, S.M.B., Ibrahim, M.E. and Blackwell, J.M. (2011) Genetic and Functional Evidence Implicating DLL1 as the Gene That Influences Susceptibility to Visceral Leishmaniasis at Chromosome 6q27. Journal of Infectious Diseases, Aug;204(3):467-77.
Marie S Rye, Selma P Wiertsema, Elizabeth SH Scaman, Joyce Oommen, Wendy Sun, Richard W Francis, Wei Ang, Craig E Pennell, David Burgner, Peter Richmond, Shyan Vijayasekaran, Harvey L Coates, Steve D Brown, Jenefer M Blackwell & Sarra E Jamieson (2011). FBXO11, a regulator of the TGFβ pathway, is associated with severe otitis media in Western Australian children. Genes and Immunity (2011) 12, 352-359.
Fakiola M, Mishra A, Rai M, Singh SP, O'Leary RA, Stephen Ball, Richard W. Francis, Martin J. Firth, Ben T. Radford, E. Nancy Miller, Shyam Sundar, Jenefer M. Blackwell. (2010) Classification and Regression Tree and Spatial Analyses Reveal Geographic Heterogeneity in Genome Wide Linkage Study of Indian Visceral Leishmaniasis. PLoS ONE 5(12): e15807. doi:10.1371/journal.pone.0015807.
Amy L Samuels, Violet K Peeva, Rachael A Papa, Martin J Firth, Richard W Francis, Alex H Beesley, Richard B Lock and Ursula R Kees (2010). Validation of a Mouse Xenograft Model System for Gene Expression Analysis of Human Acute Lymphoblastic Leukaemia. BMC Genomics Apr 21;11:256.
Kozik P, Francis RW, Seaman MNJ, Robinson MS (2010). A screen for endocytic motifs. Traffic Jun;11(6):843-55.
Smith AN, Francis RW, Sorrell SL, Karet FE (2008). The d subunit plays a central role in human vacuolar H+-ATPases. J Bioenerg Biomembr Aug;40(4):371-80.
Loos RJ, Franks PW, Francis RW, Barroso I, Gribble FM, Savage DB, Ong KK, O'Rahilly S, Wareham NJ (2007). TCF7L2 polymorphisms modulate proinsulin levels and β-cell function in a British Europid population. Diabetes Jul;56(7):1943-7.