Asthma, allergy and respiratory disorders

Asthma, allergy and respiratory disorders

 

Asthma 1Asthma, allergies and respiratory disorders (such as Cystic Fibrosis) affect millions of Australians, especially children.

 

Our researchers are dedicated to investigating how and why these conditions develop in order to provide new treatments and eventually prevent them from occuring altogether.

 

Asthma is a highly complex disease that can have a devastating impact on children and their families. In Australia, more than two million people suffer with this chronic condition.

Our team of experts is leading the world in trialling a new asthma vaccine and carrying out specialised lung function tests. Read more about our asthma research...

 

 

Our Inflammation research group is focussed on the effects of ultraviolet radiation and vitamin D3 on the immune system, with their ground-breaking work showing that small UV doses, equivalent to a short period in the midday sun, can be protective against developing asthmatic symptoms. Read more about UV and inflammation...

 

Allergies can cause a range of symptoms, from a mild inconvenience to a life-threatening reaction. Our researchers investigate common childhood allergens and examine how they might be a trigger for more serious conditions. Read more about our allergy research...

 

Cystic Fibrosis is a devastating condition that leads to premature lung damage and severely impacts the child's quailty of life and the lives of their loved ones. Our researchers are looking at ways to protect the lungs from early damage and improve the outlook for children with CF. Read more about our Cystic Fibrosis research...

 

 

 

Deputy Director: Professor Patrick Holt


Inflammation Team:

Professor Prue Hart, Head of Group

Dr Shelley Gorman, Brightspark Foundation Research Fellow

 

Molecular Biotechnology Team:

Professor Wayne Thomas, Head of Group

 

Paediatric Respiratory Physiology Team:
Professor Graham Hall,  Head of Group
Shannon Simpson, Research Officer
Kathyrn Ramsey, Research Officer
Elisha White, Research Officer
Andrew Wilson, Paediatric Respiratory Physician

 

Respiratory Environmental Health Team:

Dr Graeme Zosky

Dr Alex Larcombe


Cystic Fibrosis Team:
Professor Stephen Stick, Head of Group, Senior Principal Investigator, PMH Head of Respiratory Medicine
Dr Anthony Kicic, Senior Research Officer
Dr Clair Lee, Clinical Research Manager
Dr Erika Sutanto, Research Officer

 

Human Immunology Team:
Dr Elysia Hollams
Dr Danny Mok

Systems Biology Team:
Dr Anthony Bosco
Dr Kathy McKenna

Experimental Models Team:
Dr Debbie Strickland
Dr Vanessa Fear
Dr Karen Schuepp

  • Th2-associated immunity to bacteria in asthma in teenagers and susceptibility to asthma
    Bacterial colonisation of the airways is associated with increased risk of childhood asthma.  Read more
  • The role of dendritic cells and regulatory T cells in the regulation of allergic asthma
    Airways hyperresponsiveness (AHR) is one of the major clinical features of allergic airways disease including allergic asthma, however the immunological mechanisms leading to the induction and regulation of this disorder are not fully understood  Read more
  • Providing feedback on adherence increases use of preventive medication by asthmatic children
    This study investigates the impact of measuring adherence and providing feedback on medication usage by children with unstable asthma.  Read more
  • 1,25-dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responses
    The severity of allergic diseases may be modified by vitamin D. However, the immune pathways modulated by the active form of vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], are yet to be fully elucidated.  Read more
  • Early immunological influences on asthma development: opportunities for early intervention
    Early immunological influences on asthma development: opportunities for early intervention  Read more
  • Toward improved prediction of risk for atopy and asthma among preschoolers: A prospective cohort study
    Atopy and asthma are commonly initiated during early life, and there is increasing interest in the development of preventive treatments for at-risk children. However, effective methods for assessing the level of risk in individual children are lacking.  Read more
  • Interactions between innate and adaptive immunity in asthma pathogenesis: new perspectives from studies on acute exacerbations
    Asthma is a complex multigenic disease. The most frequently encountered form is atopic asthma, which is at its highest prevalence during childhood/young adulthood, and this represents the main focus of this review.  Read more
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  • Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium
    Damage to airway epithelium is followed by deposition of extracellular matrix (ECM) and migration of adjacent epithelial cells. We have shown that epithelial cells from children with asthma fail to heal a wound in vitro.  Read more
  • Association between socioeconomic status and the development of asthma: analyses of income trajectories
    Using data on 2868 children born in the Western Australian Pregnancy Cohort (Raine) Study, we examined the association between changes in family socioeconomic status and childhood asthma.  Read more
  • Immune-modifying properties of topical vitamin D: Focus on dendritic cells and T cells
    Topical creams containing the active form of vitamin D (1,25-dihydroxyvitamin D3; 1,25(OH)2D3) or analogues of this compound are currently used with some success to treat skin conditions including psoriasis and vitiligo.  Read more

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