Infectious disease

Infectious disease

 

Our infectious disease researchers are involved in understanding the inner workings of disease, including the pathway from immunity to infection; disease surveillance; risk factors in the development of disease; vaccine development and trials.

 

The global threat of swine flu renewed awareness about the threat of infectious diseases, particularly for the very young and the elderly.

Infectious diseases are still the most common cause of death in children and the most common reason that children under two years of age are admitted to hospital.

Worldwide, 10 million children under the age of five die from infection each year.

 

 

We use a comprehensive range of methods in our research including (epi)genetics and genomics, molecular and cellular biology, epidemiology and microscopy to explore a range of diseases including

 

  • otitis media (middle ear infections)
  • neonatal sepsis
  • respiratory infections
  • meningitis
  • toxoplasmosis and
  • leishmaniasis

 

Our Infectious Diseases Community Reference Group informs the wider community about research conducted and for community members to provide researchers with their valuable input into research projects.

 

Infectious disease

 

Our Vaccine Trials Group aims to improve the health of the community through immunisation and the prevention of infectious diseases, including:

 

  • Ross River Virus
  • Meningitis
  • Influenza
  • Dengue Fever

 

 

 

The Meningitis Centre aims to eliminate meningitis in Australia. Meningitis is a potentially deadly disease that, given its sudden onset and flu-like symptoms, is difficult to diagnose. If left untreated it has the potential to leave victims with long term disabilities or even worse, lose their lives.

The Meningitis Centre is dedicated to educating the community to be aware of the signs and symptoms, provides support for families affected by the disease and advocates for prevention through vaccination.

 

Read more about meningitis and the work of the Meningitis Centre...

 

 

Related media releases

 

 

Epidemiology Research Team:

 

Head: Associate Professor Deborah Lehmann


Dr Hannah Moore, NHMRC Early Career Fellow

Dr Anke Hoskins
Deirdre Collins
Peter Jacoby, Statistics
Kirsten Alpers
Janice Lim

Wendy (Wenxing) Sun, Research Assistant, Kalgoorlie

Ruth Monck, Research Assistant, "Pina Palya, Pina Kulilku, (Good Ear, Good Learning) project", Kalgoorlie

Lorraine Sholson, Research Assistant, "Pina Palya, Pina Kulilku, (Good Ear, Good Learning) project", Kalgoorlie

 

Vaccine Trials Group:

 

Head: Dr Peter Richmond

 

Meet the dedicated team of experienced doctors, nurses, scientists, researchers, phlebotomists, pharmacists, and administration staff.

See the full staff list

  • Histiologic chorioamnionitis is associated with reduced incidence of late-onset sepsis in very preterm infants
    Histologic chorioamnionitis (HCA) is implicated in the onset of preterm labor and delivery. Chorioamnionitis is a known risk factor for early-onset sepsis and may modulate postnatal immunity. Preterm infants are at greatly increased risk of late-onset sepsis (LOS), particularly with coagulase-negative staphylococci (CoNS), but the impact of HCA on the risk of LOS is unknown.  Read more
  • Pandemic influenza H1N1 2009 infection in Victoria, Australia: No evidence for harm or benefit following receipt of seasonal influenza vaccine in 2009
    Conflicting findings regarding the level of protection offered by seasonal influenza vaccination against pandemic influenza H1N1 have been reported. We performed a test-negative case control study using sentinel patients from general practices in Victoria to estimate seasonal influenza vaccine effectiveness against laboratory proven infection with pandemic influenza.  Read more
  • Determinants of attenuation in the envelope protein of the flavivirus Alfuy
    Murray Valley encephalitis virus (MVEV) is a mosquito-borne flavivirus endemic to Australia and Papua New Guinea. Most strains of MVEV cause potentially fatal cases of encephalitis in humans and horses, and have been shown to be highly neuroinvasive in weanling mice.  Read more
  • Predominance of nontypeable haemophilus influenzae in children with otitis media following introduction of a 3+0 pneumococcal conjugate vaccine schedule
    In Australia the 7-valent pneumococcal conjugate vaccine (PCV7) is administered at 2, 4 and 6 months of age, with no booster dose. Information on bacterial carriage and the aetiology of recurrent acute otitis media (rAOM) after introduction of PCV7 using the 3. +. 0 schedule is required to evaluate the potential impact of second generation pneumococcal vaccines.  Read more
  • Pneumococcal conjugate vaccination at birth in a high-risk setting: No evidence for neonatal T-cell tolerance
    Concerns about the risk of inducing immune deviation-associated "neonatal tolerance" as described in mice have restricted the widespread adoption of neonatal vaccination.  Read more
  • No evidence for association between SLC11A1 and visceral leishmaniasis in India
    SLC11A1 has pleiotropic effects on macrophage function and remains a strong candidate for infectious disease susceptibility. 5' and/or 3' polymorphisms have been associated with tuberculosis, leprosy, and visceral leishmaniasis (VL).  Read more
  • Reactogenicity of two 2010 trivalent inactivated influenza vaccine formulations in adults
    The objective of this tudy was to assess the reactogenicity of two 2010 trivalent inactivated influenza vaccine (TIV) formulations among adults, including the formulation associated with febrile convulsions among children in Australia.  Read more
  • Preterm infants have deficient monocyte and lymphocyte cytokine responses to group B streptococcus
    Group B streptococcus (GBS) is an important cause of early- and late-onset sepsis in the newborn. Preterm infants have markedly increased susceptibility and worse outcomes, but their immunological responses to GBS are poorly defined. We compared mononuclear cell and whole-blood cytokine responses to heat-killed GBS (HKGBS) of preterm infants (gestational age [GA], 26 to 33 weeks), term infants, and healthy adults.  Read more
  • Innate immunity in human newborn infants: prematurity means more than immaturity
    Neonates, particularly those born prematurely, are exquisitely vulnerable to life-threatening infections  Read more
  • Maternal, umbilical cord and neonatal inflammatory and hematologic markers in histologic chorioamnionitis
     Read more

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