A

The Aboriginal Collaborative Council Advising on Research and Evaluation (ACCARE) has a primary goal of facilitating, translating and applying research findings into policy and practice.

Three members of the Australian research team visited Beijing in early 2010 to continue collaborative efforts with the Beijing research team. As part of this ongoing collaboration with China, a study investigating the pathways leading to a diagnosis of Rett syndrome in China was recently completed.

Researchers in the Childhood Cancer Epidemiology program have been analysing the data collected between 2003 and 2007 in this national case-control study into the causes of childhood acute lymphoblastic leukaemia (ALL).

A series of studies from our group have established the important principle that asthma is potentially a preventable disease, if appropriate treatments can be instituted in its early stages during which long-term patterns of asthma-associated lung funtion(s) are “programmed” irreversibly in young children.

Chronic innocuous aeroallergen exposure attenuates CD4+ T cell-mediated airways hyperresponsiveness in mice, however the mechanism(s) remain unclear.

Despite significant improvements in the treatment of T-cell acute lymphoblastic leukaemia (T-ALL), as many as 30% of paediatric and 50-70% of adult patients develop treatment-resistant disease, which carries a dismal prognosis.

The primary objective of this project is to describe the aetiology, burden and causal pathways of ALRI in Aboriginal and non-Aboriginal children from a 10-year birth cohort (245, 249 births) using population linked data from the Western Australian Data Linkage System.

This project aims to understand the mechanism linking arsenic exposure in early life and chronic lung disease. We are investigating the effect of arsenic on lung growth and susceptibility to early life viral infection.

The Australian Early Development Index (AEDI) is a population measure of young children's development.

The Australian Study of Childhood Brain Tumours (AUS-CBT) was a national, NHMRC funded, case-control study of childhood brain tumours (CBT) conducted between 2006 and 2011.

In order to investigate the link between early life As exposure and the development of lung disease in later life we conducted a series of experiments using mouse models of in utero as exposure.

This multi-centre study is investigating the changes in retinopathy, aortic intima media thickness (aIMT) and heart rate variability which are indicators of macrovascular disease and autonomic neuropathy respectively; which are complications of type 1 diabetes.

The Australian Childhood Diabetes DNA Repository (ACDDR) is aiming to collect DNA samples from Australian families affected by diabetes. Families with a child with either type 1 or type 2 diabetes are invited to participate.

This is an international clinical trial with the primary objectives of determining whether intervention with Angiotensin Converting Enzyme Inhibitors (ACEI), Statins, or a combination of both, when compared with placebo will....

Asthma is a highly complex disease that can have a devastating impact on children and their families.

Research in the Molecular Biotechnology area encompasses studies on the mechanisms of allergy and the development of methods to treat or prevent diseases resulting from these processes.

The aim of the study is to investigate if measurements of lung function and airway inflammation in infancy are predictive of the development of childhood asthma at seven years of age.

A collaboration of Princess Margaret Hospital (PMH) and Telethon Institute for Child Health Research researchers has produced, in consultation with clinicians nationwide, a standardised form to record the clinical features of CP.

The 'Sonic hedgehog' pathway earned its name after researchers observed that cells of fruit flies, which carry a mutation in the gene encoding hedgehog ligand, have a spiky appearance.

This project sought to have a greater understanding of the cultural barriers and perceptions regarding organ and tissue donation among Aboriginal people, and identify the barriers some Aboriginal people experience or perceive with the current organ donor registration process.

The Alcohol and Pregnancy Project (2006-2008) provided educational resources for Western Australian (WA) health professionals to inform them about the prevention of prenatal alcohol exposure and Fetal Alcohol Spectrum Disorder (FASD).

The primary aim of this study is to determine whether PCV10 and PCV13 (which include 10 or 13 pneumococcal serotypes, respectively) are safe and immunogenic in Papua New Guinean infants for the serotypes in the respective vaccines.

The purpose of this research project is to assess whether the current child health services meet the needs of WA parents and identify why parents are not accessing child health services at key developmental ages (scheduled contacts at 18 months and 3 years).

Aboriginal health research: Developmental Pathways in WA Children Project

Due to the escalation of mental health issues in children, Desiree commenced a PhD through UWA and the Telethon Institute for Child Health Research on the risk factors and outcomes of children and adolescents diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) in Western Australia.