- Extending the reach of public health genomics: what should be the agenda for public health in an era of genome-based and "personalized" medicine?
December 1, 2010
The decade following the completion of the Human Genome Project has been marked by divergent claims about the utility of genomics for improving population health
Read more - Classification and regression tree and spatial analyses reveal geographic heterogeneity in genome wide linkage study of Indian visceral leishmaniasis
December 1, 2010
Genome wide linkage studies (GWLS) have provided evidence for loci controlling visceral leishmaniasis on Chromosomes 1p22, 6q27, 22q12 in Sudan and 6q27, 9p21, 17q11-q21 in Brazil. Genome wide studies from the major focus of disease in India have not previously been reported.
Read more - Host and parasite genomics, an Australasian perspective
August 1, 2010
The last decade has seen rapid advances in the genetic technology that is allowing researchers to examine host-pathogen interactions at a whole organism level.
Read more - Evidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosis
July 1, 2010
Congenital Toxoplasma gondii infection can result in intracranial calcification, hydrocephalus and retinochoroiditis. Acquired infection is commonly associated with ocular disease.
Read more - The -2518bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil
July 1, 2010
Mucosal leishmaniasis (ML) follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. Proinflammatory responses mediate CL self-healing but are exaggerated in ML.
Read more - P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages
June 1, 2010
The P2X7R is highly expressed on the macrophage cell surface, and activation of infected cells by extracellular ATP has been shown to kill intracellular bacteria and parasites.
Read more - Lentivirus-mediated gene transfer of interleukin 10 to the ovine and human cornea
May 1, 2010
Gene transfer to a donor cornea ex vivo can modulate corneal graft failure in experimental animal models. We compared a lentiviral vector (LV) carrying the transgene ovine interleukin 10 (IL10) with a comparable adenoviral vector (Ad) for its ability to transduce ovine and human corneas and to modulate ovine corneal allograft survival.
Read more - Detecting genotyping error using measures of degree of Hardy-Weinberg disequilibrium - art. no. 5
January 6, 2010
Tests for Hardy-Weinberg equilibrium (HWE) have been used to detect genotyping error, but those tests have low power unless the sample size is very large.
Read more - Interleukin 10 gene polymorphisms and development of post kala-azar dermal leishmaniasis in a selected sudanese population
January 1, 2010
Post kala-azar dermal leishmaniasis (PKDL) is a cutaneous form of disease that develops at variable times after individuals have received treatment for clinical visceral leishmaniasis (VL). The study aimed to investigate the possible role of interleukin 10 (IL-10) and development of PKDL.
Read more - CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study
January 1, 2010
L. braziliensis causes cutaneous (CL) and mucosal (ML) leishmaniasis. Wound healing neutrophil (PMN) and macrophage responses made following the bite of the vector sand fly contribute to disease progression in mice. To look at the interplay between PMN and macrophages in disease progression in humans we asked whether polymorphisms at genes that regulate their infiltration or function are associated with different clinical phenotypes.
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